{"id":4281,"date":"2022-01-18T17:54:28","date_gmt":"2022-01-19T01:54:28","guid":{"rendered":"http:\/\/www.puravidaaquatic.com\/wordpress\/?p=4281"},"modified":"2022-01-18T18:33:16","modified_gmt":"2022-01-19T02:33:16","slug":"mechanism-of-molnupiravir-induced-sars-cov-2-mutagenesis-pubmed","status":"publish","type":"post","link":"https:\/\/www.puravidaaquatic.com\/wordpress\/mechanism-of-molnupiravir-induced-sars-cov-2-mutagenesis-pubmed\/","title":{"rendered":"Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis – PubMed"},"content":{"rendered":"

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Molnupiravir is an orally available antiviral drug candidate currently in phase III trials for the treatment of patients with COVID-19. Molnupiravir increases the frequency of viral RNA mutations and impairs SARS-CoV-2 replication in animal models and in humans. Here, we establish the molecular mech \u2026<\/p><\/blockquote>\n

Source: Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis – PubMed<\/a><\/em><\/p>\n

Biochemical assays show that the RdRp uses the active form of molnupiravir, \u03b2-D-N4-hydroxycytidine (NHC) triphosphate, as a substrate instead of cytidine triphosphate or uridine triphosphate. When the RdRp uses the resulting RNA as a template, NHC directs incorporation of either G or A, leading to mutated RNA products.<\/p><\/blockquote>\n

It not only mutates the viral genome RNA but it also mutates your own human cells RNA.<\/p>\n

1) The very cells in your body that are working the hardest to express new RNA are your immune system cells trying to generate templates for antibody production to fight the virus. This drug cannot be good for your immune system.<\/p>\n

2) covid-19 is obviously an RNA virus. Because of the chemical nature of RNA and proofreading factors, RNA viruses already mutate approximately 10 times faster than DNA organisms. This high rate of mutation allows them to generate potential variants more quickly. I definitely question trying to increase their rate of mutagenesis. Especially with the likelihood of missed dosages and other factors of the real world.<\/p>\n

And in one of my other posts http:\/\/www.puravidaaquatic.com\/wordpress\/report-says-monsanto-linked-pesticide-is-to-blame-for-microcephaly-outbreak-not-zika\/<\/a> I speculated that one of the unforeseen problems with the real world versus scientific research was the issue of chlorination. I would bet very few scientific labs research the reaction of chlorinated tap water with the drug products they are working on.<\/p>\n","protected":false},"excerpt":{"rendered":"

Molnupiravir is an orally available antiviral drug candidate currently in phase III trials for the treatment of patients with COVID-19. Molnupiravir increases the frequency of viral RNA mutations and impairs SARS-CoV-2 replication in animal models and in humans. Here, we … Continue reading →<\/span><\/a><\/p>\n

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